Chakkupurayil Radhakrishnan was born on 15 February 1939 in Chamravattom (a village in Tirur) in Malapuram District, which was then a part of the Madras Presidency of British India), to Parappur Madathil Madhavan Nair and Chakkupurayi Janaki Amma. He heard from his grandparents that Ezhuthachan was an ancestor in his lineage, and this and other details of the information imparted to him formed the basis for creation of one of his works: the biography of Tunjathu Ramanujan Ezhuthachan titled Theekkadal Kadanhu Thirumadhuram.
Radhakrishnan wrote his first novel Nizhalppadukal at the age of 21 in 1959 while pursuing his post graduate degree. The book was initially published serially in a magazine and later published by Current Books in 1962. The book became a runaway hit and was the winner of Kerala Literary Academy in 1962.
In July 2014, Radhakrishnan was awarded the Moortidevi Award for the year 2013 for his novel Theekkadal Kadanhu Thirumadhuram. He was conferred the Ezhuthachan Puraskaram for the year 2016. Other literary recognitions include the Mathrubhumi Literary Award in 2015, K.P.Kesava Menon memorial award in 2016, the Madhava Mudra, Nalappadan Award and Thrikkavu Devi Puraskaram.